The pathogenesis of atherosclerosis and consequent cardiovascular incidents is now an established fact, with the rupturing of vulnerable plaques leading to variable coronary flow, a fact that distinguishes between the three forms of ACS. With the resultant thrombosis, it is critical for the interventionalist to know when to resort to PCI. The clinician must determine what causes the rupture: inflammation, infection or some other factor. Handbook of the Vulnerable Plaque defines vulnerable plaque, explains how can it be detected and who are likely candidates for vulnerable plaque. All the contributors to this volume are respected worldwide for their work in this field.